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KMID : 0988920070050020170
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Intestinal Research
2007 Volume.5 No. 2 p.170 ~ p.176
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Factors Affecting the Efficacy of Tegaserod in Patients with Chronic Constipation
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Choi Hwang
Han Dong-Soo
Jean Yoon-Tae
Seol Sang-Yong
Lee Won-Chul
Kim Hyo-Jong
Kim Joo-Sung
Chang Dong-Kyung
Yang Suk-Kyun
Kim Jin-Ho
Kim Jin-Oh
Yoon Sang-Heon
Kim Won-Ho
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Abstract
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Background:The effect of tegaserod has been found to differ for Caucasian and black patients. The aims of this study were to demonstrate the efficacy of tegaserod on bowel habits and to investigate the factors affecting the efficacy of tegaserod in Korean patients suffering from chronic constipation (CC).
Method:This was an open-label, multi-center, observational study. Analysis of covariance with repeated measures was used to determine the overall effect of treatment and was used to determine the changes in the number of complete spontaneous bowel movements (CSBM) from baseline during the 8-week treatment period. Demographic and baseline characteristics were compared between responders (3 or more CSBM at 8-weeks) and non-responders by the use of multivariate analysis.
Results: A total of 1,798 patients were included in the study. Tegaserod treatment resulted in a significant increase in the mean number of CSBM per week over weeks 2-8 from baseline levels (from 1.0 to 3.1 CSBM per week, p＜0.0001). Tegaserod treatment was more effective for female patients, younger patients (age less than 65 years), patients with a high Bristol score at baseline, and patients with a short duration of constipation symptoms.
Conclusions: Treatment with tegaserod improved bowel movements and more effective in female patients, patients under the age of 65 years, patients with a high Bristol score at baseline, and patients with a short duration of constipation symptoms.
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KEYWORD
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Constipation, Tegaserod, Bowel Movement
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